The development of OA is rarely the result of a single factor but rather a combination of systemic and local biomechanical stressors.

• Age: The risk increases significantly as people get older due to the cumulative stress on joints and a decreased ability of cartilage to repair itself.

• Obesity: Carrying extra weight puts added stress on weight-bearing joints (knees and hips). Furthermore, fat tissue produces proteins that can cause harmful inflammation in and around the joints.

• Joint Injuries: Injuries from sports or accidents, even those that happened years ago, can increase the risk of OA.

• Genetics: Some individuals inherit a tendency to develop OA or have a genetic defect in the production of collagen, a key component of cartilage.